Orlistat is a prescription weight loss medication that is used to help people lose weight. It works by blocking the absorption of fat in the stomach, reducing the amount of fat that is absorbed into the body. Orlistat is available in two forms: capsules and pellets. The capsule form is usually taken twice a day with meals, while the pellet form is usually taken once a day with meals. The pellets form is more convenient and easier to take, since it can be taken with food or without food. Orlistat can help people lose up to 10 percent of their body weight over a period of six months. It is important to note that orlistat should only be used with a reduced-calorie diet and regular exercise, in order to achieve the best results.